The novel Sky Pirates! takes place in a world that seems insane and comical. It turns out that it is so truly insane and horrific that the human mind cannot cope, so it makes up something nicer for us to believe.
It turns out that our minds do the same thing when we look at the Doctor and the TARDIS. A character get’s a glimpse of his true body and cannot stop screaming.
I wish this idea had caught on, I love the idea of a Lovecraftian Doctor. He’s still a loving hero but also a cosmic and biological mess.